Severe signs include severe hyperthermia, seizures, central nervous system (CNS) depression, coma, cardiorespiratory depression, muscle rigidity and myoclonus. Signs of moderate disease include altered mental status, tachypnea, vomiting, dysrhythmias, hyperthermia, and hypertension. Mild signs include agitation, diaphoresis, tachycardia and mild temperature elevation. Signs of MAOI toxicity are non-specific as well.
A complete list of medications, supplements, both current and recently discontinued, should be obtained as there can be significant latency between ingestions and development of symptomatology.
Though many of the symptoms of MAOI toxicity are nonspecific, much of the suspicion for MAOI toxicity will come from the patient history.
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